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Molecular mechanisms of complement evasion: learning from staphylococci and meningococci

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Publication date

2010

Authors

Serruto, D.
Rappuoli, R.
Scarselli, M.
Gros, PietISNI 0000000395560467
van Strijp, J.A.G.

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DOI

https://doi.org/10.1038/nrmicro2366

Document Type

Article

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Abstract

The complement system is a crucial component of the innate immune response in humans. Recent studies in Staphylococcus aureus and Neisseria meningitidis have revealed how these bacteria escape complement-mediated killing. In addition, new structural data have provided detailed insights into the molecular mechanisms of host defence mediated by the complement system and how bacterial proteins interfere with this process. This information is fundamental to our understanding of bacterial pathogenesis and may facilitate the design of better vaccines.

Keywords

SDG 3 - Good Health and Well-being

Citation

Serruto, D, Rappuoli, R, Scarselli, M, Gros, P & van Strijp, J A G 2010, 'Molecular mechanisms of complement evasion: learning from staphylococci and meningococci', Nature Reviews Microbiology, vol. 8, pp. 393-399. https://doi.org/10.1038/nrmicro2366

URI

https://dspace.library.uu.nl/handle/1874/197058