Design specifications for biomedical virtual twins in engineered adoptive cellular immunotherapies
Publication date
2025-08-01
Authors
Weirauch, Ulrike
Kreuz, Markus
Birkenbihl, Colin
Alb, Miriam
Quaranta, Maria
Calzone, Laurence
Orozco-Ruiz, Sophia
Binder, Stefanie
Fischer, Luise
Clavreul, Solène
Editors
Advisors
Supervisors
Document Type
Article
Metadata
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License
cc_by
Abstract
In (immune)oncology, virtual twins (VTs) offer patient-individual decision support. Nevertheless, current VTs do not incorporate the unique properties of engineered adoptive cellular immunotherapies (eACIs). Here, we outline the minimal design specifications for VTs for engineered ACIs (eACI-VTs) to model the complex interplay between cell product and patient physiology. We motivate utilizing VTs in eACIs to provide decision support and reflect on how eACI-VTs can support the widespread use of eACIs.
Keywords
Medicine (miscellaneous), Health Informatics, Computer Science Applications, Health Information Management, Journal Article, Review
Citation
Weirauch, U, Kreuz, M, Birkenbihl, C, Alb, M, Quaranta, M, Calzone, L, Orozco-Ruiz, S, Binder, S, Fischer, L, Clavreul, S, Maguri, M, Ferle, M, Rade, M, Azarias, G, Hydren, J R, Jamarik, J, Schwarz, D, Sebestyen, Z, Kuball, J, Popp, G, Antoine, C, Knockaert, M, Schoeder, C T, Fandrei, D, Sanges, C, Radvilas, V, Gagelmann, N, Rückert, M, Penack, O, Fricke, S, Schmidt, A, Ward, C, Steinbeisser, C, Van Gyseghem, J-M, Niarakis, A, Garderet, L, Hudecek, M, Neumuth, T, Platzbecker, U, Köhl, U, Demlova, R, Kremer, A, Franke, S, Fröhlich, H, Merz, M, Reiche, K & CERTAINTY Consortium 2025, 'Design specifications for biomedical virtual twins in engineered adoptive cellular immunotherapies', npj digital medicine, vol. 8, no. 1, 493. https://doi.org/10.1038/s41746-025-01809-6