A Perspective on the Added Value of Red Blood Cells during Cardiac Hypothermic Oxygenated Perfusion
Publication date
2025-02
Authors
Vervoorn, Mats
Ballan, Elisa Maria
Kaffka Genaamd Dengler, S E
Meijborg, Veronique M.F.
Jager, Saskia Christel Antoinette de
Van Wijk, Richard
van der Kaaij, Niels
Editors
Advisors
Supervisors
Document Type
Editorial
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taverne
Abstract
Hypothermic oxygenated perfusion (HOPE) is an emerging technique for donor heart preservation that is currently being studied in multiple clinical trials with promising results. When compared to HOPE for other organs, cardiac protocols involve red blood cell (RBC) supplementation, despite absence of comparative evidence for its benefits. In this perspective paper, we discuss the pros and cons of the addition of RBCs during cardiac HOPE. Although the current clinical results with RBC supplementation during HOPE seem promising, potential downsides of RBC supplementation cannot be ruled out. The impact of supplemented RBCs during cardiac HOPE requires further investigation to improve HOPE protocols, to optimize heart preservation using this promising technology.
Keywords
cardiac HOPE, donor heart preservation, ex-situ heart perfusion, heart transplantation, red blood cells, Taverne, Cardiology and Cardiovascular Medicine, Transplantation, Pulmonary and Respiratory Medicine, Surgery
Citation
Vervoorn, M T, Ballan, E M, Kaffka Genaamd Dengler, S E, Meijborg, V M F, de Jager, S C A, Van Wijk, R & van der Kaaij, N P 2025, 'A Perspective on the Added Value of Red Blood Cells during Cardiac Hypothermic Oxygenated Perfusion', The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, vol. 44, no. 2, pp. 285-288. https://doi.org/10.1016/j.healun.2024.09.025