Reproductive Complications in Childhood Cancer Survivors
Publication date
2020-12
Authors
Van Santen, Hanneke M.
van de Wetering, Marianne D
Bos, Annelies M
van den Heuvel-Eibrink, Marry M
van der Pal, Helena J
Wallace, William Hamish
Editors
Advisors
Supervisors
Document Type
Article
Metadata
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Abstract
Gonadal dysfunction and infertility after cancer treatment are major concerns for childhood cancer survivors and their parents. Uncertainty about fertility or being diagnosed with infertility has a negative impact on quality of survival. In this article, determinants of gonadal damage are reviewed and consequences for fertility and pregnancies are discussed. Recommendations for screening and treatment of gonadal function are provided. These should enable timely treatment of gonadal insufficiency aiming to improve linear growth, pubertal development, and sexual functioning. Options for fertility preservation are discussed.
Keywords
Childhood cancer survivor, Fertility preservation, Gonadal failure, Infertility, Late effects, Premature ovarian failure, Radiation effects, Pediatrics, Perinatology, and Child Health
Citation
van Santen, H M, van de Wetering, M D, Bos, A M E, Vd Heuvel-Eibrink, M M, van der Pal, H J & Wallace, W H 2020, 'Reproductive Complications in Childhood Cancer Survivors', The pediatric clinics of North America, vol. 67, no. 6, pp. 1187-1202. https://doi.org/10.1016/j.pcl.2020.08.003