Polymeric Nanogels with Tailorable Degradation Behavior
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Publication date
2016-08-01
Authors
Chen, Y.
van Steenbergen, Mies J.
Li, Dandan
Van Den Dikkenberg, Joep
Lammers, Twan
van Nostrum, Cornelus F
Metselaar, Josbert M.
Hennink, Wim E.
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Article
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taverne
Abstract
The aim of this study is to design a polymeric nanogel system with tailorable degradation behavior. To this end, hydroxyethyl methacrylate-oligoglycolates-derivatized poly(hydroxypropyl methacrylamide) (pHPMAm-Gly-HEMA) and hydroxyethyl methacrylamide-oligoglycolates-derivatized poly(hydroxyethyl methacrylamide) (pHEMAm-Gly-HEMAm) are synthesized and characterized. pHEMAm-Gly-HEMAm shows faster hydrolysis rates of both carbonate and glycolate esters than the same ester groups of pHPMAm-Gly-HEMA. pHEMAm-Gly-HEMAm nanogels have tailorable degradation kinetics from 24 h to more than 4 d by varying their crosslink densities. It is shown that the release of a loaded macromolecular model drug is controlled by degradation of nanogels. The nanogels show similar cytocompatibility as PLGA nanoparticles and are therefore considered to be attractive systems for drug delivery. (Figure presented.).
Keywords
biodegradable, crosslink density, cytocompatibility, drug delivery systems, polymeric nanogels, Taverne, Biotechnology, Bioengineering, Biomaterials, Polymers and Plastics, Materials Chemistry
Citation
Chen, Y, van Steenbergen, M J, Li, D, van den Dikkenberg, J, Lammers, T, van Nostrum, C F, Metselaar, J M & Hennink, W E 2016, 'Polymeric Nanogels with Tailorable Degradation Behavior', Macromolecular Bioscience, vol. 16, no. 8, pp. 1122-1137. https://doi.org/10.1002/mabi.201600031