Linear neutralizing epitopes on the peplomer protein of coronaviruses
Publication date
1990-12-01
Authors
Posthumus, W. P A
Meloen, R. H.
Enjuanes, L.
Correa, I.
van Nieuwstadt, A. P.
Koch, G.
de Groot, R.J.
Kusters, J. G.
Luytjes, W.
Spaan, W. J.
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Part of book
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Abstract
Three years ago, we reported a comparison of the primary structures of the S peplomer proteins of three coronaviruses - mouse hepatitis virus (MHV, strain A59), infectious bronchitis virus (IBV, strain M41), and feline infectious peritonitis virus (FIPV, strain 79-1146) - which represent the three antigenic clusters in the Coronavirus family (De Groot et al., 1987a, b). A periodicity in the C-terminal part of the S sequence indicated the presence of a coiled-coil structure, which forms the stalk of the peplomer. The nonconserved N-terminal sequence probably forms the bulbous part of the peplomer.
Keywords
Infectious Bronchitis Virus, Antigenic Site, Hybrid Protein, Linear Epitope, Mouse Hepatitis Virus, General Biochemistry,Genetics and Molecular Biology, SDG 3 - Good Health and Well-being
Citation
Posthumus, W P A, Meloen, R H, Enjuanes, L, Correa, I, van Nieuwstadt, A P, Koch, G, de Groot, R J, Kusters, J G, Luytjes, W, Spaan, W J, van der Zeijst, B A M & Lenstra, J A 1990, Linear neutralizing epitopes on the peplomer protein of coronaviruses. in Coronaviruses and their Diseases. Advances in Experimental Medicine and Biology, vol. 276, Springer, pp. 181-188. https://doi.org/10.1007/978-1-4684-5823-7_25