Insertion/deletion polymorphism of the ACE gene and adherence to ACE inhibitors
Publication date
2005-04
Authors
Schelleman, H
Klungel, Olaf H.
van Duijn, C M
Witteman, J C M
Hofman, A
de Boer, Anthonius
Stricker, B H Ch
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Supervisors
Document Type
Article
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Abstract
AIMS: We investigated whether the insertion/deletion (I/D) polymorphism of the ACE gene modified the adherence to ACE inhibitors as measured by the discontinuation of an ACE inhibitor, or addition of another antihypertensive drug. METHODS: This was a cohort study among 239 subjects who started ACE inhibitor therapy. A Cox proportional hazard model was used to calculate relative risk (RR). RESULTS: During follow-up there was no significant difference between subjects with the DD, ID or II genotype (DD vs II; RR = 1.17, 95%CI: 0.78, 1.77 and ID vs II; RR = 1.06, 95%CI: 0.73, 1.55) in adherence. CONCLUSIONS: The I/D polymorphism of the ACE gene does not influence the adherence to ACE inhibitors.
Keywords
Aged, Analysis of Variance, Angiotensin-Converting Enzyme Inhibitors, Antihypertensive Agents, Cohort Studies, DNA Transposable Elements, Gene Deletion, Genotype, Humans, Hypertension, Middle Aged, Patient Compliance, Polymerase Chain Reaction, Polymorphism, Genetic, Prospective Studies, Risk Assessment
Citation
Schelleman, H, Klungel, O H, van Duijn, C M, Witteman, J C M, Hofman, A, de Boer, A & Stricker, B H C 2005, 'Insertion/deletion polymorphism of the ACE gene and adherence to ACE inhibitors', British Journal of Clinical Pharmacology, vol. 59, no. 4, pp. 483-485. https://doi.org/10.1111/j.1365-2125.2004.02332.x