Protein–Protein Docking with HADDOCK
Publication date
2012-03-14
Authors
Schmitz, C.
Melquiond, Adrien S J
de Vries, S.J.
Karaca, E.
van Dijk, M.
Kastritis, Panagiotis L
Bonvin, Alexandre M.J.J.
Editors
Bertini, Ivano
McGreevy, Kathleen S.
Parigi, Giacomo
Advisors
Supervisors
Document Type
Part of book
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Abstract
Advances in biophysics and biochemistry have pushed back the limits of the structural characterization of biomolecular assemblies. Mixing even a limited amount of experimental and/or bioinformatics data with modeling methods such as macromolecular docking represents a valuable strategy to predict the three-dimensional structures of complexes. In this chapter, we discuss the HADDOCK data-driven approach to the modeling of complexes. The program supports a wide range of NMR and other experimental data as well as bioinformatics predictions. It is also available as a user-friendly web server, facilitating the modeling of biomolecular complexes for a wide community.
Keywords
protein–protein docking, HADDOCK, bioinformatics, macromolecular docking, three-dimensional structure, web server, biomolecular modeling, Taverne
Citation
Schmitz, C, Melquiond, A S J, de Vries, S J, Karaca, E, van Dijk, M, Kastritis, P & Bonvin, A M J J 2012, Protein–Protein Docking with HADDOCK. in I Bertini, K S McGreevy & G Parigi (eds), NMR of biomolecules : towards mechanistic systems biology. Wiley, Weinheim, pp. 520-535. https://doi.org/10.1002/9783527644506.ch32