Discordant NIPT result in a viable trisomy-21 pregnancy due to prolonged contribution to cfDNA by a demised trisomy-14 cotwin
Publication date
2018-05
Authors
Hochstenbach, Ron
Elferink, Martin G
van Zon, Patrick H A
Lichtenbelt, Klaske
van Harssel, Jeske
Schuring-Blom, G. H.
Christiaens, G. C.M.Lieve
Editors
Advisors
Supervisors
Document Type
Article
Metadata
Show full item recordCollections
License
Abstract
One of the confounders in noninvasive prenatal testing (NIPT) is the vanishing twin phenomenon. Prolonged contribution to the maternal Cell-free DNA (cfDNA) pool by cytotrophoblasts representing a demised, aneuploid cotwin may lead to a false-positive outcome for a normal, viable twin. We show that a vanishing trisomy-14 twin contributes to cfDNA for more than 2 weeks after demise.
Keywords
Cell-free DNA, false-positive result, noninvasive prenatal testing, vanishingtwin
Citation
Hochstenbach, R, Elferink, M G, van Zon, P H A, Lichtenbelt, K D, van Harssel, J, Schuring-Blom, H & Page-Christiaens, G C M L 2018, 'Discordant NIPT result in a viable trisomy-21 pregnancy due to prolonged contribution to cfDNA by a demised trisomy-14 cotwin', Clinical case reports, vol. 6, no. 5, pp. 788-791. https://doi.org/10.1002/ccr3.1424