Thymic stromal lymphopoietin as a novel mediator amplifying immunopathology in rheumatic disease
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Publication date
2015-10
Authors
Hillen, Maarten R.
Radstake, Timothy R D J
Hack, Cornelis E.
Van Roon, J. A G
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Document Type
Article
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taverne
Abstract
Thymic stromal lymphopoietin (TSLP) is an IL-7-related cytokine that has been studied extensively in atopic diseases and more recently in various rheumatic disorders. It is involved in T cell development in the thymus and promotes homeostatic T cell expansion by classical dendritic cells. However, deregulated TSLP expression in various rheumatic diseases has implicated this cytokine as a strong mediator in immunopathology. Overexpressed TSLP induces strong T cell activation and production of pro-inflammatory cytokines in human cells and animal models for RA, SSc and LN, underscoring the therapeutic potential of targeting the TSLP-TSLP receptor axis.
Keywords
Dendritic cells, Immunopathology, T cells, Thymic stromal lymphopoietin, Taverne, Rheumatology, Pharmacology (medical), Journal Article, Research Support, Non-U.S. Gov't, Review
Citation
Hillen, M R, Radstake, T R D J, Hack, C E & van Roon, J A G 2015, 'Thymic stromal lymphopoietin as a novel mediator amplifying immunopathology in rheumatic disease', Rheumatology (Oxford, England), vol. 54, no. 10, pp. 1771-1779. https://doi.org/10.1093/rheumatology/kev241