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Association between inhaled long-acting beta-2-agonists and the risk of acutemyocardial infarction: A methodological comparison of two databases

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Publication date

2014-10-01

Authors

Afonso, Ana S.M.
Schmiedl, Sven
Becker, Claudia
Primatesta, Paola
Plana, Estel
Souverein, Patrick C.
Korevaar, Joke C.
Hasford, Joerg
Reynolds, Robert
De Groot, Mark C. H.ORCID 0000-0002-5764-5788ISNI 0000000010971418

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DOI

https://doi.org/10.1002/pds.3701

Document Type

Abstract

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Abstract

Background: Results from multiple observational studies on inhaled long-acting beta-2-agonists (LABA) and the risk of acute myocardial infarction (AMI) are conflicting, due to variations in methodological, clinical and health care characteristics. To some extent, the discrepancies in the design might limit the comparability of the results encountered. Objectives: To determine the risk of AMI in inhaled LABA users in two European electronic primary care databases using a common study protocol. Methods: Patients from the Dutch Mondriaan (1.4 Million) and the UK CPRD (5 Million) databases were included if they had a diagnosis of asthma and/or COPD, and were prescribed at least one inhaled LABA, a short-acting beta-2-agonist (SABA), or a short- or long-acting muscarinic antagonist (SAMA, LAMA) during the study period (2002 to 2009). LABA episodes were divided into current, recent (

Keywords

beta 2 adrenergic receptor stimulating agent, muscarinic receptor blocking agent, risk, infarction, data base, pharmacoepidemiology, risk management, human, patient, asthma, implantable cardioverter defibrillator, prescription, drug therapy, primary medical care, potential difference, health care, acute heart infarction, morbidity, model, proportional hazards model, diagnosis, United Kingdom, confidence interval, hazard ratio, observational study, SDG 3 - Good Health and Well-being

Citation

Afonso, A S M, Schmiedl, S, Becker, C, Primatesta, P, Plana, E, Souverein, P C, Korevaar, J C, Hasford, J, Reynolds, R, De Groot, M C H, Schlienger, R G, Klungel, O H & Rottenkolber, M 2014, 'Association between inhaled long-acting beta-2-agonists and the risk of acutemyocardial infarction: A methodological comparison of two databases', Pharmacoepidemiology and Drug Safety, vol. 23, no. S1, 727, pp. 390-391. https://doi.org/10.1002/pds.3701

URI

https://dspace.library.uu.nl/handle/1874/303482