Comparisons of oxygen gradient ektacytometry parameters between sickle cell patients with or without α-thalassaemia
Publication date
2021-11
Authors
Boisson, Camille
Renoux, Céline
Nader, Elie
Gauthier, Alexandra
Poutrel, Solène
Rab, M A E
Fort, Romain
Bertrand, Yves
Stauffer, Emeric
Cannas, Giovanna
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Advisors
Supervisors
Document Type
Article
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taverne
Abstract
The present study tested the impact of α-thalassaemia on oxygen gradient ektacytometry in sickle cell anaemia (SCA). Three SCA groups were compared: (i) no α-thalassaemia (four α-genes, n = 62), (ii) silent α-thalassaemia (three α-genes, n = 35) and (iii) homozygous α-thalassaemia (two α-genes, n = 12). Red blood cell (RBC) deformability measured in normoxia was not different between the three groups. The lowest RBC deformability reached at low oxygen partial pressure (pO2 ) was greater and the pO2 at which RBC started to sickle was lower in the two α-genes group compared to the other groups. Our present study showed an effect of α-thalassaemia on oxygen gradient ektacytometry in SCA.
Keywords
red blood cell deformability, sickle cell disease, sickling, α-thalassaemia, Taverne, Hematology, Journal Article
Citation
Boisson, C, Renoux, C, Nader, E, Gauthier, A, Poutrel, S, Rab, M, Fort, R, Bertrand, Y, Stauffer, E, Cannas, G, Kebaili, K, Virot, E, Hot, A, Sheehan, V, van Beers, E, van Wijk, R, Joly, P & Connes, P 2021, 'Comparisons of oxygen gradient ektacytometry parameters between sickle cell patients with or without α-thalassaemia', British Journal of Haematology, vol. 195, no. 4, pp. 629-633. https://doi.org/10.1111/bjh.17777