Sorting out polarized transport mechanisms in neurons

Abstract

Neurons are highly polarized cells with two distinct processes called axons and dendrites. To establish and maintain their specialized morphology and function, neurons use molecular motors: kinesins, myosins and dynein to steer cargo transport along the cytoskeleton into axons and dendrites. However, little is known about how specific cargos are directed into the distinct compartments of the neuronal cell. The work presented in this thesis focuses on investigating the molecular mechanisms of regulation of the intracellular transport in neurons. Here, we identify novel regulatory mechanisms for cargo-motor, motor-cytoskeleton and motor-motor interaction necessary for proper neuronal sorting, development and function.