Clinical Characteristics, Treatment Considerations, and Outcomes of Infants with Rhabdomyosarcoma
Publication date
2023-04
Authors
Yan, Adam P.
Venkatramani, Rajkumar
Bradley, Julie A.
Lautz, Timothy B.
Urla, Cristian I.
Merks, Johannes H.M.
Oberoi, Sapna
Editors
Advisors
Supervisors
Document Type
Article
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Abstract
RMS most commonly presents in children and adolescents, however a subset of tumors are diagnosed in infants under one year of age. Due to the rarity of infant RMS, utilization of different treatment approaches and goals, and small sample sizes, the published studies of infants with RMS have yielded heterogeneous results. In this review, we discuss the outcomes of infants with RMS treated in various clinical trials and the strategies that various international cooperative groups have employed to reduce the morbidity and mortality related to treatment without compromising the overall survival of this population. This review discusses the unique scenarios of diagnosing and managing congenitals or neonatal RMS, spindle cell RMS and relapsed RMS. This review concludes by exploring novel approaches to diagnosis and management of infants with RMS that are currently being studied by various international cooperative groups.
Keywords
infant, pediatric, rhabdomyosarcoma, sarcoma, Oncology, Cancer Research
Citation
Yan, A P, Venkatramani, R, Bradley, J A, Lautz, T B, Urla, C I, Merks, J H M & Oberoi, S 2023, 'Clinical Characteristics, Treatment Considerations, and Outcomes of Infants with Rhabdomyosarcoma', Cancers, vol. 15, no. 8, 2296. https://doi.org/10.3390/cancers15082296