Vascular extracellular vesicles in comorbidities of heart failure with preserved ejection fraction in men and women: The hidden players. A mini review
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Publication date
2018-12
Authors
Gohar, Aisha
de Kleijn, Dominique
Hoes, A.
Rutten, Frans H
Hilfiker-Kleiner, Denise
Ferdinandy, Péter
Sluijter, Joost
den Ruijter, Hester M.
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Document Type
Article
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taverne
Abstract
Left ventricular diastolic dysfunction, the main feature of heart failure with preserved ejection fraction (HFpEF), is thought to be primarily caused by comorbidities affecting the endothelial function of the coronary microvasculature. Circulating extracellular vesicles, released by the endothelium have been postulated to reflect endothelial damage. Therefore, we reviewed the role of extracellular vesicles, in particularly endothelium microparticles, in these comorbidities, including obesity and hypertension, to identify if they may be potential markers of the endothelial dysfunction underlying left ventricular diastolic dysfunction and HFpEF.
Keywords
Comorbidities, Endothelial microparticles, HFpEF, LVD, Sex, Taverne, Physiology, Molecular Medicine, Pharmacology
Citation
Gohar, A, de Kleijn, D P V, Hoes, A W, Rutten, F H, Hilfiker-Kleiner, D, Ferdinandy, P, Sluijter, J P G & den Ruijter, H M 2018, 'Vascular extracellular vesicles in comorbidities of heart failure with preserved ejection fraction in men and women : The hidden players. A mini review', Vascular pharmacology, vol. 111, pp. 1-6. https://doi.org/10.1016/j.vph.2018.05.006