Case Report: Immune dysregulation associated with long-lasting regression of a (pre)leukemic clone
Publication date
2023-10-16
Authors
Koedijk, Joost B
van Beek, Thomas B
Vermeulen, Marijn A
Kester, Lennart A
Schweighart, Elizabeth K
Nierkens, Stefan
Belderbos, Mirjam E.
Zwaan, C. Michel
Heitink-Pollé, Katja M J
Heidenreich, Olaf
Editors
Advisors
Supervisors
Document Type
Article
Metadata
Show full item recordCollections
License
cc_by
Abstract
Regression of leukemia in the absence of disease-modifying therapy remains poorly understood, although immunological mechanisms are thought to play a role. Here, we present a unique case of a 17-year-old boy with immune dysregulation and long-lasting regression of a (pre)leukemic clone in the absence of disease-modifying therapy. Using molecular and immunological analyses, we identified bone marrow features associated with disease control and loss thereof. In addition, our case reveals that detection of certain fusion genes with hardly any blasts in the bone marrow may be indicative of an accompanying oncogenic fusion gene, with implications for disease surveillance- and management in future patients.
Keywords
Adolescent, Bone Marrow, Clone Cells, Humans, Leukemia, Male, acute myeloid leukemia, childhood, immune-mediated, spontaneous remission, case report, Immunology and Allergy, Immunology, Case Reports, Research Support, Non-U.S. Gov't
Citation
Koedijk, J B, van Beek, T B, Vermeulen, M A, Kester, L A, Schweighart, E K, Nierkens, S, Belderbos, M E, Zwaan, C M, Heitink-Pollé, K M J & Heidenreich, O 2023, 'Case Report : Immune dysregulation associated with long-lasting regression of a (pre)leukemic clone', Frontiers in Immunology, vol. 14, 1280885, pp. 1-6. https://doi.org/10.3389/fimmu.2023.1280885