ADAM10 gene expression in the blood cells of Alzheimer's disease patients and mild cognitive impairment subjects
Files
Publication date
2015-01-01
Authors
Manzine, Patricia Regina
Marcello, Elena
Borroni, Barbara
Kamphuis, Willem
Hol, Elly
Padovani, Alessandro
Nascimento, Carla Crispim
De Godoy Bueno, Patricia
Assis Carvalho Vale, Francisco
Iost Pavarini, Sofia Cristina
Editors
Advisors
Supervisors
Document Type
Article
Metadata
Show full item recordCollections
License
taverne
Abstract
ADAM10 is a potential biomarker for Alzheimer's disease (AD). ADAM10 protein levels are reduced in platelets of AD patients. The aim was to verify the total blood and platelet ADAM10 gene expression in AD patients and to compare with mild cognitive impairment (MCI) and healthy subjects. No significant differences in ADAM10 gene expression were observed. Therefore, the decrease of ADAM10 protein in platelets of AD patients is not caused by a reduction in ADAM10 mRNA. Further studies must be performed to investigate other pathways in the down regulation of ADAM10 protein.
Keywords
Aging, biomarkers, blood, platelets, Taverne, Biochemistry, Clinical Biochemistry, Health, Toxicology and Mutagenesis
Citation
Manzine, P R, Marcello, E, Borroni, B, Kamphuis, W, Hol, E, Padovani, A, Nascimento, C C, De Godoy Bueno, P, Assis Carvalho Vale, F, Iost Pavarini, S C, Di Luca, M & Cominetti, M R 2015, 'ADAM10 gene expression in the blood cells of Alzheimer's disease patients and mild cognitive impairment subjects', Biomarkers, vol. 20, no. 3, pp. 196-201. https://doi.org/10.3109/1354750X.2015.1062554