2nd update to RIFM fragrance ingredient safety assessment, 3,7-dimethyl-1,6-nonadien-3-ol, CAS Registry Number 10339-55-6

Abstract

3,7-Dimethyl-1,6-nonadien-3-ol was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, photoirritation/photoallergenicity, skin sensitization, and environmental safety. Target data and data from read-across analog linalool (CAS # 78-70-6) show that 3,7-dimethyl-1,6-nonadien-3-ol is not expected to be genotoxic. Data on read-across analog linalool (CAS # 78-70-6) provide a calculated Margin of Exposure (MOE) > 100 for the repeated dose toxicity, reproductive toxicity, and local respiratory toxicity endpoints and show that there are no safety concerns for 3,7-dimethyl-1,6-nonadien-3-ol for skin sensitization under the current declared levels of use. The photoirritation/photoallergenicity endpoints were evaluated based on ultraviolet/visible (UV/Vis) spectra; 3,7-dimethyl-1,6-nonadien-3-ol is not expected to be photoirritating/photoallergenic. The environmental endpoints were evaluated; 3,7-dimethyl-1,6-nonadien-3-ol was found not to be Persistent, Bioaccumulative, and Toxic (PBT) as per the International Fragrance Association (IFRA) Environmental Standards, and its risk quotients, based on its current volume of use (VoU) in Europe and North America (i.e., Predicted Environmental Concentration/Predicted No Effect Concentration [PEC/PNEC]), are <1.