Clonality of anti-GM1 IgM antibodies in multifocal motor neuropathy and the Guillain-Barré syndrome
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Publication date
2015-05-01
Authors
Cats, Elisabeth A.
van der Pol, W Ludo
Tio-Gillen, Anne P.
Diekstra, Frank P.
van den Berg, Leonard
Jacobs, Bart C.
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Article
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taverne
Abstract
Objective Multifocal motor neuropathy (MMN) and the Guillain-Barré syndrome (GBS) are immune-mediated motor neuropathies with antibodies against the ganglioside GM1. In GBS, these antibodies are induced by molecular mimicry, but in MMN their origin is elusive. Methods We compared the light-chain use of anti-GM1 IgM antibodies in serum from 42 patients with MMN and 23 patients with GBS by ELISA. Results Exclusive use of either κ or λ light chains was found in 38 (90%) patients with MMN and 9 (39%) with GBS (p<0.001). Conclusions Anti-GM1 IgM antibodies in most patients with MMN are produced by only a single or very limited number of B-cell clones, whereas in most patients with GBS, anti-GM1 IgM antibodies are most likely polyclonal.
Keywords
Taverne, Surgery, Arts and Humanities (miscellaneous), Clinical Neurology, Psychiatry and Mental health
Citation
Cats, E A, Van Der Pol, W L, Tio-Gillen, A P, Diekstra, F P, Van Den Berg, L H & Jacobs, B C 2015, 'Clonality of anti-GM1 IgM antibodies in multifocal motor neuropathy and the Guillain-Barré syndrome', Journal of Neurology, Neurosurgery and Psychiatry, vol. 86, no. 5, pp. 502-504. https://doi.org/10.1136/jnnp-2014-308118