Interference of the galactose-dependent binding of lectins by novel pentapeptide ligands
Publication date
2004-03-22
Authors
Arnusch, Christopher J.
André, Sabine
Valentini, Paola
Lensch, Martin
Russwurm, Roland
Siebert, Hans-Christian
Fischer, Marcel J. E.
Gabius, Hans-Joachim
Pieters, Roland J
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Document Type
Article
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Abstract
A library of pentapeptides containing the sequence -Y-X-Y- based on rational design was screened with six different lectins. Sequences were identified that modulate galectin binding to its natural carbohydrate ligand. SPR showed inhibition values 2-3 times stronger than galactose and NMR studies suggested real carbohydrate mimicry. © 2004 Elsevier Ltd. All rights reserved.
Keywords
carbohydrate, galactose, galectin, lectin, ligand, pentapeptide, amino acid sequence, article, library, nuclear magnetic resonance, protein analysis, protein binding, protein modification
Citation
Arnusch, C J, André, S, Valentini, P, Lensch, M, Russwurm, R, Siebert, H-C, Fischer, M J E, Gabius, H-J & Pieters, R J 2004, 'Interference of the galactose-dependent binding of lectins by novel pentapeptide ligands', Bioorganic and Medicinal Chemistry Letters, vol. 14, no. 6, pp. 1437-1440. https://doi.org/10.1016/j.bmcl.2004.01.029