Synthesis of bicyclic tripeptides inspired by the ABC-ring system of vancomycin through ruthenium-based cyclization chemistries
Publication date
2017-11-29
Authors
Yang, Xin
Beroske, Lucas P.
Kemmink, Johan
Rijkers, Dirk
Liskamp, Rob
Editors
Advisors
Supervisors
Document Type
Article
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Abstract
The synthesis of a bicyclic tripeptide that mimics the ABC ring system of vancomycin is described by using a ring closing metathesis (RCM) – peptide coupling – ruthenium-catalyzed azide-alkyne cycloaddition (RuAAC) strategy.
Keywords
Macrocycles, Peptides, Peptidomimetics, Ring-closing metathesis, Ru-based azide-alkyne cycloaddition, Biochemistry, Drug Discovery, Organic Chemistry
Citation
Yang, X, Beroske, L P, Kemmink, J, Rijkers, D T S & Liskamp, R M J 2017, 'Synthesis of bicyclic tripeptides inspired by the ABC-ring system of vancomycin through ruthenium-based cyclization chemistries', Tetrahedron Letters, vol. 58, no. 48, pp. 4542-4546. https://doi.org/10.1016/j.tetlet.2017.10.046