A novel ruthenium(III) complex with a tridentate dianionic P,O,O-ligand showing high cytotoxic activity
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Publication date
2009
Authors
van Rijn, J.A.
Marqués-Gallego, Patricia
Reedijk, J.
Lutz, M.
Bouwman, E.
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Article
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Abstract
Tris(o-anisyl)phosphane was reacted with ruthenium(III) chloride forming a novel Ru(III) complex of formula [Ru(PAn3)(P(An)(phenolate)2)Cl] containing a tridentate dianionic P,O,O-ligand and a bidentate neutral P,O ligand. The tridentate ligand was formed by elimination of two methyl groups from the starting ligand in the reaction with the ruthenium salt. The molecular structure was determined by single crystal X-ray diffraction analysis. The compound shows a high cytotoxic activity in ovarian cancer cell lines comparable with cisplatin and overcoming cisplatin-resistance.
Keywords
SDG 3 - Good Health and Well-being
Citation
van Rijn, J A, Marques Gallego, P, Reedijk, J, Lutz, M & Bouwman, E 2009, 'A novel ruthenium(III) complex with a tridentate dianionic P,O,O-ligand showing high cytotoxic activity', Dalton Transactions, vol. 2009, pp. 10727-10730.