In Vivo Generation of Post-infarct Human Cardiac Muscle by Laminin-Promoted Cardiovascular Progenitors
Publication date
2019-03-19
Authors
Yap, Lynn
Wang, Jiong Wei
Moreno-Moral, Aida
Chong, Li Yen
Sun, Yi
Harmston, Nathan
Wang, Xiaoyuan
Chong, Suet Yen
Öhman, Miina K.
Wei, Heming
Editors
Advisors
Supervisors
Document Type
Article
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License
cc_by
Abstract
Yap et al. perform in vitro differentiation of pluripotent embryonic stem cells to cardiovascular progenitors using laminin-221 as a culture matrix in a fully human and chemically defined protocol. Use of these cells for in vivo cardiac regeneration and to generate human heart muscle bundles results in improved heart function.
Keywords
cardiovascular progenitors, hESC-based cardiac muscle regeneration, laminin, regenerative cardiology, General Biochemistry,Genetics and Molecular Biology
Citation
Yap, L, Wang, J W, Moreno-Moral, A, Chong, L Y, Sun, Y, Harmston, N, Wang, X, Chong, S Y, Öhman, M K, Wei, H, Bunte, R, Gosh, S, Cook, S, Hovatta, O, de Kleijn, D P V, Petretto, E & Tryggvason, K 2019, 'In Vivo Generation of Post-infarct Human Cardiac Muscle by Laminin-Promoted Cardiovascular Progenitors', Cell Reports, vol. 26, no. 12, pp. 3231-3245.e9. https://doi.org/10.1016/j.celrep.2019.02.083