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Scedosporium infection as a late complication after start of elexacaftor/tezacaftor/ivacaftor: two case reports

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1-s2.0-S2213007125001145-main.pdf (1.01 MB)

Publication date

2025-01

Authors

Van Mourik, Peter
van der Hout, E C
Luijk, Bart
Hofland, Regina W.
Bruns, AnkeISNI 0000000395587782
Heijerman, H.
Bronsveld, InezISNI 0000000394975230

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DOI

https://doi.org/10.1016/j.rmcr.2025.102278

Document Type

Article

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Abstract

Highly effective modulator treatment (HEMT) has resulted in an improved prognosis for people with cystic fibrosis (pwCF). In this case report, we present two pwCF with clinical stabilization after start of HEMT who developed complicated fungal infections after several years of clinical stability, highlighting the importance of continued careful monitoring of pwCF on HEMT and considering early antifungal treatment in this population.

Keywords

Cystic fibrosis, Elexacaftor/tezacaftor/ivacaftor, Scedosporium, Pulmonary and Respiratory Medicine, Case Reports, Journal Article

Citation

van Mourik, P, van der Hout, E C, Luijk, H D, Hofland, R W, Bruns, A H W, Heijerman, H G M & Bronsveld, I 2025, 'Scedosporium infection as a late complication after start of elexacaftor/tezacaftor/ivacaftor : two case reports', Respiratory Medicine Case Reports, vol. 57, 102278. https://doi.org/10.1016/j.rmcr.2025.102278

URI

https://dspace.library.uu.nl/handle/1874/467551